San Francisco and New York are renowned for their vibrant comic scenes, with a rich history of comic book creation and a thriving community of comic enthusiasts.

San Francisco has been a hub for comic book culture since the 1940s, with the Golden Gate Bridge and Alcatraz Island serving as iconic backdrops for numerous comic book stories. The city's historic comic book publishers, such as National Comics and DC Comics, have contributed significantly to the industry. Additionally, San Francisco hosts numerous comic conventions and events, including the San Francisco International Film Festival, which often features comic book adaptations.

New York City, on the other hand, has been a breeding ground for comic book innovation since the 1930s. It's home to Marvel Comics, which was founded in 1939, and DC Comics, which was established in 1934. The city's diverse population has inspired countless comic book characters and storylines. New York's comic culture is further bolstered by its numerous comic book stores, conventions, and the annual New York Comic Con, one of the largest comic book events in the world.

Data from the Comic Book Legal Defense Fund (CBLDF) indicates that San Francisco and New York are among the top cities in the United States for comic book-related activities. According to their 2020 report, San Francisco had 12 comic book stores, while New York had 18. Additionally, the New York Comic Con attracted over 200,000 attendees in 2020, making it one of the most popular comic book events in the country. These figures highlight the cities' significant contributions to the comic book industry and their status as comic book meccas.