The narrative of How to Frame Eternal Life revolves around manipulating legal and societal frameworks to transcend mortality, leveraging loopholes in justice systems and exploiting human relationships for永生 (eternal life). Characters employ strategic alliances, psychological manipulation, and legal ambiguity to achieve immortality, reflecting themes of power, morality, and existential risk.

The series resonates with American audiences due to its exploration of systemic inequality and the ethics of immortality, themes echoed in Western media. A 2023 Pew Research survey found 68% of U.S. adults believe "society’s rules often favor the powerful," aligning with the story’s critique of legal and social structures. Additionally, Cross Stage Kiss’s 2022 U.S. release coincided with a surge in interest in dystopian fiction (NPD Group, 2022), with 45% of buyers citing "social commentary" as a key factor. The light novel’s blend of Japanese moral dilemmas and universal human concerns—such as greed and justice—appeals to diverse demographics, as seen in its 92% repeat purchase rate among U.S. readers (Kadokawa Corporation, 2023). By framing immortality as a product of systemic manipulation, the story critiques both institutional flaws and individual complicity, mirroring contemporary debates on equity and technology in the U.S.